Healthy Karyotype: Use the first image to show a normal set of chromosomes. Down Syndrome Karyotype: Use the second image to show the extra chromosome 21. Highlighting the Affected Chromosome: In both karyotypes, you can use color to highlight chromosome 21. For the Down syndrome karyotype, emphasize the third copy of chromosome 21. Meiosis Diagram: Include the third image to illustrate the nondisjunction event during meiosis that leads to trisomy 21. See more