The proposed iSecure framework enables quantum-secure key exchange and encrypted communication. The proposed framework leverages primary objectives of ensuring data privacy and system security using MDI-QKD techniques. The developed quantum network architecture is shown in Fig.~\ref{fig:topology}. The developed QKD architecture adopts a modular, zone-based design which segments key generation into key clusters, transmission, and storage into clearly defined zones (clusters), making it adaptable to constrained environments while upholding high standards of confidentiality, integrity, and authenticity of the data and individuals. \subsection{Topology and Operational Framework} We discuss the network topology and operational of the designed QKD network topology for secure data exchange between connected participants and health centres as describe in next subsections. \subsubsection{Network Topology} The proposed quantum-secure healthcare network is modeled as a multi-hop quantum communication topology, where rural health centers act as distributed routers connected through hybrid quantum and classical channels. Each router node is linked to its adjacent nodes through entangled photon sources, which are extended across the network using Bell State Measurement (BSM) stations. The BSM units, deployed between routers, execute entanglement swapping operations, thereby enabling secure key distribution between non-adjacent nodes without requiring direct quantum links. As shown in See more